Nonsteroidal anti-inflammatory drugs (NSAIDs) are a drug class that lessen pain, decrease fever, avoid blood clots and, in higher doses, decrease inflammation. Side effects be determined by the specific drug, but largely include an increased possibility of gastrointestinal ulcers and bleeds, heart attack and kidney disease.

NSAIDs work by inhibiting the action of cyclooxygenase enzymes (COX-1 and/or COX-2). In cells, these enzymes are involved in the synthesis of key biological peacekeepers, namely prostaglandins which are involved in inflammation, and thromboxanes which are involved in blood clotting.